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Cells with impaired PERK-eIF2a-ATF4 signal transduction are more sensitive to hypoxic stress in vitro , indicating that the PERK-eIF2a-ATF4 pathway provides a survival advantage for cells under hypoxic conditions (75, 76), which is crucial for resistance to intracellular hypoxia, metabolic stress, and starvation

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Semi-targeted raw data from the Metabolon platform was similarly processed with our in-house script, performing corresponding normalization for biological material based on the total integrated peak area values of high-confidence metabolites

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